Nitric Oxide Research on Human Body:
Dr. Robert F Furchgot  
American Nobel Laureate (1998)
Prof. The SUNY Health Science Center, Brooklyn.


In 1980, Dr. Furchgott published his discovery of endothetium – derived relaxing factor (EDRF) a mysterious Chemical in the inner lingings of arteries that controls the artery’s widening and narrowing. By 1986, he had worked out EDRF’s nature and mechanism and, from his 6th floor lab at the SUNY Health science Center at Brooklyn, announced that EDRF was in fact the tiny molecule nitric oxide (NO) Between those years, laboratories around the globe were detailing EDRF’s importance in the body’s physiology, from regulating blood pressure to preventing blood clots.

In 1996, Dr. Robert F. Furchgott received the Albert Lasker Basic ‘Medical Research Award for his work at SUNY Downstate Medical Center in discovering, Nitric Oxide.

The foremost is Dr. Robert F. Furchgott of Brooklyn Hospital, New York, who discovered Nitric Oxide (NO) in the human body for the first time in the world. For this discovery Dr. Furchgott received the1998 Nobel Prize for Medicine. Nitric Oxide (NO) functions as a signaling molecule in the cardiovascular system. Dr. Furchgott made the breakthrough discovery in 1998 that blood vessels are widened by Nitric Oxide (NO) thereby relaxing the blood vessels and effecting good blood flow. In 1998, another pioneer, Dr. John Garthwaite of the Liverpool Institute, London, discovered, for the first time ever, Nitric Oxide (NO) in the brain. He further discovered that Nitric Oxide (NO) plays a remarkable role as a messenger between brain cells, carrying information and improving connectivity.

  • Dr. Robert F. Furchgott  – Letter of  VALIDATION  Click Here.
Nitric Oxide Research on Human Brain:
Prof. John Garthwaite
Professor of Experimental Neuro Science
Wolfson Institute for Biomedical Research – Division of Medicine – LONDON, UK.


There are two main lines of research: (a) Nitric oxide signaling in the Brain, and (b) The pharmacology of voltage-gated Sodium Channels.

Nitric Oxide signaling in the Brain: Nitric Oxide is a majortransmitter in the central nervous system and, accordingly, is involved in a host of different functions, including learning and memory formation, feeding, sleeping, male and female reproductive behavior, as well as in sensory and motor function. Some of these roles have been conserved through millions of years of evolution, in some cases dating back to animals with the most primitive nervous systems. Many clinical conditions (e.g. neurodegenerative and some psychiatric disorders) are also thought to involve aberrant nitric oxide transmission.

The major part of our research is directed towards understanding how this signaling system operates in the brain at the cellular and molecular levels. There are several specific research projects, using a broad range of techniques (chiefly molecular biology, electrophysiology, immunocytochemistry and biochemistry), which can be categorized as follows:

 1.Measuring Nitric Oxide Signals: A major deficiency is a lack of understanding of the nature of Nitric Oxide signals in the Brain, for example their amplitude and duration. We are developing new biosensors that offer unparalleled sensitivity and specificity for this purpose.

 2.Molecular Pharmacology of Nitric Oxide Receptors: As with any transmitter, understanding how its receptors function is vital for decoding the language of communication. The receptor proteins designed to detect Nitric Oxide contain an intrinsic gauntly cyclase catalytic domain and so generate Cyclic GMP on stimulation. The receptors provide an astonishing degree of amplification of even brief (sub-second), low amplitude (sub-Nano molar) nitric oxide signals

  • Dr. John Garthwaite – Letter of VALIDATION Click Here.


Memory Plus was extensively researched by other renowned institutes. Clinical trials of Memory Plus conducted on groups of people revealed amazing results! The group taking Memory Plus showed significant improvements in mental tests. Even TIME magazine (May 5, 1997) reported on the amazing effects of Memory Plus on school students.
Click the links below to know more

  • Clinical Study In Elderly Subjects.
  • Clinical trials with Healthy Male Volunteers.
  • Clinical Trails on Children.

  • CLINICAL TRIAL REPORT click here  


  • Pierce Wright on Nitric Oxide – Read Article.
  • ITRC – Stress Reduction through NO – Read Article. 
  • Endothelial Cells as Mediators of Vasodilation – Read Article.
  • Endothelial Cells as Mediators of Vasodilatation of Arteries for PDF – Read Article.


The general concept of a systemic patholphysiological response to cerebral  damage was first developed almost 150 years ago (1). Currently there are several cellular and molecular responses to acute cerebral injury  have been identified. While some of the cellular responses to cerebral ischemia occur with in 15 sec. In animal models (2), increased catabolic hormone release probably occurs within a few minutes, while the cardiovascular response such as changes in blood pressure (BP) occur in 20 min. (3) However, other responses such as the cerebral inflammatory responses only begin after 20-24 hrs (4). While a response to injury may be construed as a healing process, these responses to the injury need not always be beneficial, in some instances they may add to faster deterioration of neuronal functions if the cells are not pre -primed with defensive mechanisms. Thus prevention of these deleterious effects caused after the injury or the preventive measures that reduce the damage caused by injury will have very useful clinical application. One of the preventive measures is to administer medication that enhances the protective / defensive mechanisms of the cells.

Neuronal degeneration need not always be a consequence of physical accident but can also be consequence of aging process. Aging is associated with cognitive impairments and manifestation of neurodegenerative diseases like Alzheimer’s (AD) (5) and Parkinson (PD) (6). The biochemical and molecular changes that accompany the aging process are currently being identified in various laboratories around the globe with the intention of either elimination or retardation of the age induced cognitive impairments. Some mutations in certain genes such as Werner’s disease may add to faster aging process, mutations in certain genes does not take place for aging to occur. Aging is a natural process which involves changes in gene expression. Thus regulation of gene expression is one of the ways to counter the age associated disabilities. Regulation of these biochemical and molecular changes that take place during aging should, in theory, automatically retard or even reverse the cognitive impairments thus reducing the chances of becoming victims of age associated diseases like AD and PD.

 Click Here To know More…..



“I Trust Memory Plus”.
Viswanathan Anand – World Chess Grand Master– 1996.
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  • Prince Mongosuthu Buthelezi South Africa – Click Here
  • Sri I K Gujral former Prime Minister of IndiaClick Here

Footy Hero
Adam Ritson,  Australia
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Hon'ble Prime Minister Sri P. V. Narasimha Rao Launched & Endorsed MEMORY PLUS on 28th Feb. 1996. at New Delhi .

Hon’ble Prime Minister Sri P. V. Narasimha Rao Launched & Endorsed MEMORY PLUS on 28th Feb. 1996. at New Delhi .

"Promises a healthy & prosperous nation"

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